TYROS 1

Tyrosine-and phenylalanine-free, iron fortified infant formula with DHA and ARA for infants and young children with documented tyrosinemia type I and type II.

Indication

Tyrosine-and phenylalanine-free, iron fortified infant formula with DHA and ARA for infants and young children with documented tyrosinemia type I and type II.

Product Forms


Product	Format	Unit Size	Approximate Product Yield at Normal Dilution	Shelf Life	Item Number
TYROS 1	Powder	454 g	Yield Not Applicable to Metabolics	18 Months	2001957

Preparation Of Feedings

POWDER

Mead Johnson TYROS 1 is to be used only in the dietary management of infants and young children with tyrosinemia Type I and Type II under the direct and continuing supervision of your baby’s doctor.

WARNING: This product is nutritionally incomplete. Care must be taken to provide enough phenylalanine and tyrosine to support growth, using other foods with these amino acids as required. Your doctor must carefully and constantly supervise use of TYROS 1 with other foods and adjust the diet based on frequent blood tests.

Your baby’s health depends on carefully following the instructions below. Proper hygiene, preparation, dilution, use and storage are important when preparing formula. Powdered formulas are not sterile and should not be fed to premature infants or those persons who might have immune problems unless directed and supervised by your baby’s doctor.

Preparation Image:

Preparation Description:

1. Wash hands thoroughly. Boil clean bottles, nipples, caps and utensils in water (2 minutes at a rolling boil).

Preparation Image:

Preparation Description:

2. Boil fresh water at a rolling boil for 2 minutes. Cool to room temperature prior to mixing.

Preparation Image:

Preparation Description:

3. Pour desired amount of the cooled water into the bottle. Add powder. Cap bottle and shake vigorously.

Your baby’s doctor will provide instructions for the correct amount of water and powder. Each scoop (unpacked and level) delivers approximately 4.5 g of powder.

Failure to follow these instructions could result in severe harm. Once prepared, formula can spoil quickly. Either feed immediately or cover and store in refrigerator at 2-4°C (35-40°F) for no longer than 24 hours. Do not use prepared formula if it is unrefrigerated for more than a total of 2 hours. Do not freeze prepared formula. After feeding begins, do not refrigerate feeding bottle. You must use within 1 hour or discard.

WARNING: Do not use a microwave oven to warm formula. Serious burns may result.

STORAGE: Store cans at room temperature. After opening can, keep tightly covered, store in dry area and use contents within one month. Do not freeze powder and avoid excessive heat.

WARNING: Not for parenteral (I.V.) use.

Nutrients


Analysis	per 100 mL	per 100 g
Energy (kcal/kJ)	68/280	500/2090
Protein equivalent (g)	2.3	16.7
% of total energy	13	13
Source: Amino Acid Premix
Carbohydrate (g)	6.9	51
% of total energy	40	40
Source: Corn syrup solids, modified corn starch, sugar
Fat (g)	3.5	26
% of total energy	47	47
Source: Palm olein oil (44%), soy oil (19.5%), coconut oil (19.5%), high oleic sunflower oil (14.5%), ARA & DHA single cell oil blend (2.5%)
Linoleic Acid (g)	0.54	4
Linolenic Acid (g)	0.046	0.34
ARA (mg)	24	175
DHA (mg)	11.9	88
Minerals
Calcium (mg)	89	660
Calcium (mMol)	2.2	16.5
Phosphorus (mg)	59	440
Phosphorus (mMol)	1.92	14.2
Magnesium (mg)	8.9	66
Magnesium (mMol)	0.37	2.7
Iron (mg)	1.3	9.6
Zinc (mg)	1.16	8.6
Manganese (mg)	0.051	0.38
Copper (mg)	0.116	0.86
Iodine (mg)	0.0103	0.076
Selenium (mg)	0.0019	0.0141
Sodium (mg)	32	240
Sodium (mMol)	1.41	10.4
Potassium (mg)	82	610
Potassium (mMol)	2.1	15.6
Chloride (mg)	58	430
Chloride (mMol)	1.64	12.1
Vitamins
Vitamin A (IU)	210	1520
Vitamin D (IU)	51	380
Vitamin E (IU)	1.35	10
Vitamin K (mg)	0.0054	0.044
Vitamin C (mg)	8.1	60
Thiamine (mg)	0.135	1
Riboflavin (mg)	0.135	1
Niacin (mg)	1.35	10
Pantothenic Acid (mg)	0.51	3.8
Vitamin B6 (mg)	0.135	1
Folic Acid (mg)	0.0135	0.1
Vitamin B12 (mg)	0.00027	0.002
Biotin (mg)	0.0051	0.038
Choline (mg)	16.7	124
Inositol (mg)	11.6	86
Carnitine (mg)	6.8	50
Taurine (mg)	4.1	30


Other Characteristics
Potential Renal Solute Load (mOsm/100 mL)1	20
Osmolality (mOsm/kg H2O)*	360
Osmolarity (mOsm/L)*	320
Water (g/100 mL)	90

All metabolic products are for use under the direct and continuing supervision of a doctor or metabolic dietitian.

This product is nutritionally incomplete. Care must be taken to provide enough phenylalanine and tyrosine to support growth, using other foods with these amino acids as required. Nutritional powders are not sterile.

*100 mL values and Other Characteristics information is based on this product mixed with water to a caloric density of 0.68 kcal/mL.

1. Fomon SJ, Ziegler EE. Renal solute load and potential renal solute load in infancy. J Pediatr. 1999;134:11-14.

Nutrient values are subject to change. Consult actual product labels for most current information.

Ingredients

Corn Syrup Solids, Vegetable Oil (Palm Olein Oil, Coconut Oil, Soy Oil, High Oleic Sunflower Oil), Amino Acids (L-Glutamine, L-Leucine, Potassium Aspartate, L-Lysine Hydrochloride, L-Proline, L-Valine, L-Alanine, L-Isoleucine, L-Arginine, L-Threonine, L- Serine, Glycine, L-Histidine, L-Methionine, L-Tryptophan, L-Cystine), Modified Corn Starch, Sugar, Calcium Phosphate, Mortierella Alpine Oil, Crypthecodinium Cohnii Oil*, Ethyl Vanillin, L-Carnitine, Taurine, Ascorbyl Palmitate, Mixed Tocopherols (May Contain Potassium Hydroxide), Minerals (Choline Chloride, Cupric Sulfate, Ferrous Sulfate, Inositol, Magnesium Oxide, Manganese Sulfate, Potassium Chloride, Potassium Citrate, Sodium Citrate, Sodium Iodide, Sodium Selenite And Zinc Sulfate), Vitamins (Ascorbic Acid, Biotin, Calcium Pantothenate, Folic Acid, Niacinamide, Riboflavin, Thiamine Hydrochloride, Vitamin A Palmitate, Vitamin B12, Vitamin B6 Hydrochloride, Vitamin D3, Vitamin E Acetate And Vitamin K1).

*A Source of Docosahexaenoic Acid (DHA)