1. Fast symptom management
- About 9 out of 10 infants with colic due to CMPA can be successfully managed with Nutramigen A+ with LGG, often within 48 hours*¹

2. Speed up time to cow’s milk protein acceptance, overcoming the allergy sooner^†
- More infants fed with Nutramigen A+ with LGG build oral tolerance to cow’s milk protein (CMP) after 6 and 12 months of feeding†²

3. May reduce the risk of future allergic manifestations
- Infants using Nutramigen A+ with LGG experienced a 23% reduction in risk of urticaria, rhinoconjunctivitis, eczema or asthma, in a 36 months follow-up study³

*Studied before the addition of LGG culture, DHA and ARA
†Compared to Nutramigen A+
1. Lothe L, et al. Pediatrics. 1989; 83: 262-266.
2. Berni Canani R et al. J Allergy Clin Immunol 2012;129:580–582
3. Berni Canani R et al. J Allergy Clin Immunol. 2017. doi: 10.1016/j.jaci.2016.10.050.

How does Nutramigen A+ with LGG get babies back to cow’s milk proteins fast (build oral tolerance to CMP)?
Extensively hydrolyzed proteins reduce antigen transfer while probiotics/LGG support the gut and modulate the immune response.

CMP=cow’s milk protein; LGG=Lactobacillus rhamnosus GG.
LGG is a registered trademark of Valio, Ltd.

1. Majamaa H et al. J Allergy Clin Immunol. 1997;99:179-185. 2. Isolauri E et al. J Clin Gastroenterol. 2008;42(suppl 2):S91-S96. 3. Baldassarre ME et al. J Pediatr. 2010;156:397-401. 4. Petschow B et al. J Clin Gastroenterol. 2005;39:786-790. 5. Isolauri E et al. Gastroenterology. 1993;105:1643-1650. 6. Isolauri E. Am J Clin Nutr. 2001;73(suppl):1142S-1146S.

Extensively hydrolyzed proteins reduce antigen transfer while probiotics (LGG) support the gut and modulate the immune response.

CMP = cow's milk protein: LGG = Lactobacillus rhamnosus GG
LGG is a registered trademark of Valio Ltd.
1. Berni Canani R et al. J Allergy Clin Immunol 2012;129:580–582

Download Pediatric Perspectives newsletter – special cow’s milk protein allergy edition
Outgrowing CMP allergy fast means reaching a life free from CMPA quicker.
As infants get older, the social, practical, and emotional burden of CMPA may get increasingly complicated.

1. Cummings AJ et al. Allergy. 2010;65:933–945

How can Nutramigen A+ with LGG potentially reduce the progression of the Allergic March?
Allergic diseases during infancy are a risk factor for other allergic diseases later on, a concept commonly referred to as the “Allergic March”.^1-3
Emerging evidence suggests that a combination of EHCF and LGG may alter long-term risk of allergy via modulation of gut microbiota and epigenetic mechanisms.^4,5
Infants with CMPA using Nutramigen A+ with LGG experienced a 23% reduction in risk of urticaria, rhinoconjunctivitis, eczema or asthma, in a 36 months follow-up study.⁵

1. Goksör E et al. Acta Paediatr. 2016;105:1472-1479
2. Alduraywish SA et al. Pediatr Allergy Immunol. 2017; 28:30-37
3. Somanunt S et al. Asian Pac J Allergy Immunol. 2016. doi: 10.12932/AP0825. [Epub ahead of print].
4. PaparoL.etal.ClinicalEpigenetics(2016)8:86
5. Berni Canani R et al. J Allergy Clin Immunol. 2017. doi: 10.1016/j.jaci.2016.10.050.

Download the Nutramigen A+ with LGG and the Allergic March study (Canani 2017)
Extensively hydrolyzed casein formula containing L. rhamnosus GG plays a role in reducing the occurrence of other allergic manifestations in children with cow’s milk protein allergy (CMPA): 3-year randomized controlled trial^*. ^*rhinoconjunctivitis, urticaria, eczema, and asthma in a 36 month study

Help CMPA patients manage their allergy NOW ^*,1 and overcome CMPA FASTER^† with Nutramigen A+ with LGG

^*often within 48 hours, studied before the addition of LGG culture, DHA and ARA
1. Lothe L, et al. Pediatrics. 1989; 83: 262-266.

† than Nutramigen A+