Extensively Hydrolyzed Formula (eHF) that Stands Apart

For CMPA, experts recommend eHF first line

Choose a formula that stands apart

1. Fast symptom management

- About 9 out of 10 infants with colic due to CMPA can be successfully managed with Nutramigen A+ with LGG, often within 48 hours*1

2. Speed up time to cow’s milk protein acceptance, overcoming the allergy sooner†

- More infants fed with Nutramigen A+ with LGG build oral tolerance to cow’s milk protein (CMP) after 6 and 12 months of feeding†2

3. May reduce the risk of future allergic manifestations

- Infants using Nutramigen A+ with LGG experienced a 23% reduction in risk of urticaria, rhinoconjunctivitis, eczema or asthma, in a 36 months follow-up study3

*Studied before the addition of LGG culture, DHA and ARA

†Compared to Nutramigen A+

  1. Lothe L, et al. Pediatrics. 1989; 83: 262-266.
  2. Berni Canani R et al. J Allergy Clin Immunol 2012;129:580–582
  3. Berni Canani R et al. J Allergy Clin Immunol. 2017. doi: 10.1016/j.jaci.2016.10.050.

How does Nutramigen A+ with LGG get babies back to cow’s milk proteins fast (build oral tolerance to CMP)?

Extensively hydrolyzed proteins reduce antigen transfer while probiotics/LGG support the gut and modulate the immune response.

CMP=cow’s milk protein; LGG=Lactobacillus rhamnosus GG.

LGG is a registered trademark of Valio, Ltd.

1. Majamaa H et al. J Allergy Clin Immunol. 1997;99:179-185. 2. Isolauri E et al. J Clin Gastroenterol. 2008;42(suppl 2):S91-S96. 3. Baldassarre ME et al. J Pediatr. 2010;156:397-401. 4. Petschow B et al. J Clin Gastroenterol. 2005;39:786-790. 5. Isolauri E et al. Gastroenterology. 1993;105:1643-1650. 6. Isolauri E. Am J Clin Nutr. 2001;73(suppl):1142S-1146S.

Extensively hydrolyzed proteins reduce antigen transfer while probiotics (LGG) support the gut and modulate the immune response.

CMP = cow's milk protein: LGG = Lactobacillus rhamnosus GG

LGG is a registered trademark of Valio Ltd.

1. Berni Canani R et al. J Allergy Clin Immunol 2012;129:580–582

Download Pediatric Perspectives newsletter – special cow’s milk protein allergy edition

Outgrowing CMP allergy fast means reaching a life free from CMPA quicker.

As infants get older, the social, practical, and emotional burden of CMPA may get increasingly complicated.

1. Cummings AJ et al. Allergy. 2010;65:933–945

How can Nutramigen A+ with LGG potentially reduce the progression of the Allergic March?

Allergic diseases during infancy are a risk factor for other allergic diseases later on, a concept commonly referred to as the “Allergic March”.1-3

Emerging evidence suggests that a combination of EHCF and LGG may alter long-term risk of allergy via modulation of gut microbiota and epigenetic mechanisms.4,5

Infants with CMPA using Nutramigen A+ with LGG experienced a 23% reduction in risk of urticaria, rhinoconjunctivitis, eczema or asthma, in a 36 months follow-up study.5

  1. Goksör E et al. Acta Paediatr. 2016;105:1472-1479
  2. Alduraywish SA et al. Pediatr Allergy Immunol. 2017; 28:30-37
  3. Somanunt S et al. Asian Pac J Allergy Immunol. 2016. doi: 10.12932/AP0825. [Epub ahead of print].
  4. aparoL.etal.ClinicalEpigenetics(2016)8:86
  5. Berni Canani R et al. J Allergy Clin Immunol. 2017. doi: 10.1016/j.jaci.2016.10.050.

Download the Nutramigen A+ with LGG and the Allergic March study (Canani 2017)

Extensively hydrolyzed casein formula containing L. rhamnosus GG plays a role in reducing the occurrence of other allergic manifestations in children with cow’s milk protein allergy (CMPA): 3-year randomized controlled trial*.

*rhinoconjunctivitis, urticaria, eczema, and asthma in a 36 month study

Help CMPA patients manage their allergy NOW *,1 and overcome CMPA FASTER† with Nutramigen A+ with LGG

*often within 48 hours, studied before the addition of LGG culture, DHA and ARA 1. Lothe L, et al. Pediatrics. 1989; 83: 262-266.

† than Nutramigen A+